Inflammation triggers silent mutation to cause deadly lung disease

Researchers at Stanford University Medicine have found in lungs rats, may wake up silent genetic defect sudden onset cases hypertension," said Amy Tian, research scientist in critical Inflammation triggers silent care. "Basically, second hit in arteries lungs. You can healthy carrying it leads to terrible disease. " Tian lead author study, MD, author study. important research for how 'second hits' can ordinarily silent genetic mutations.

Researchers at the Stanford University School of Medicine have found that inflammation in the lungs of rats, triggered by something as simple as the flu, may wake up a silent genetic defect that causes sudden onset cases of pulmonary hypertension, a deadly form of high blood pressure in the lungs. Tian is the lead author of the study, which will be published Aug. 29 in Circulation. Mark Nicolls, MD, professor and chief of pulmonary and critical care medicine, pulmonary heart disease is the senior author of the study. "This is important research for understanding how 'second hits' can render ordinarily silent genetic mutations deadly," Nicolls said. "It also further advances the scientific understanding of the role of inflammation in pulmonary hypertension. " Currently there is no known cause for pulmonary hypertension, a debilitating disease that causes difficulty breathing, fatigue and chest pain. It can leave patients too weakened to perform simple daily activities, such as climbing a flight of stairs.

(CNN) US health officials announced that as of August according to a Inflammation in the statement leaders from US for Disease Control US Food Drug Administration. Reports state health departments suggest total number of potential could be significantly higher, is Cases of lung an increase from week ago, health officials reporters last week. "States completing their own investigations verifications of based CDC's recently released standardized definition.